Histone deacetylase inhibitors in cancer therapy. A review.

  title={Histone deacetylase inhibitors in cancer therapy. A review.},
  author={Jan Hraběta and Marie Stiborov{\'a} and Vojtech Adam and Ren{\'e} Kizek and Tomas Eckschlager},
  journal={Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
  volume={158 2},
BACKGROUND Despite recent success toward discovery of more effective anticancer drugs, chemoresistance remains a major cause of treatment failure. There is emerging evidence that epigenetics plays a key role in the development of the resistance. Epigenetic regulators such as histone acetyltransferases (HATs) and histone deacetylases (HDACs) play an important role in gene expression. The latter are found to be commonly linked with many types of cancers and influence cancer development. Overall… CONTINUE READING
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