Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles

@inproceedings{Wang2013HistoneDI,
  title={Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles},
  author={Hui Wang and Florian Duclot and Yan Emma Liu and Zuoxin Wang and Mohamed Kamal Kabbaj},
  booktitle={Nature Neuroscience},
  year={2013}
}
In the socially monogamous prairie vole (Microtus ochrogaster), mating induces enduring pair-bonds that are initiated by partner preference formation and regulated by a variety of neurotransmitters, including oxytocin, vasopressin and dopamine. We examined potential epigenetic mechanisms mediating pair-bond regulation and found that the histone deacetylase inhibitors sodium butyrate and trichostatin A (TSA) facilitated partner preference formation in female prairie voles in the absence of… CONTINUE READING
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