Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells.

@article{Duncan2013HistoneDI,
  title={Histone deacetylase inhibitors epigenetically promote reparative events in primary dental pulp cells.},
  author={H F Duncan and Anthony J Tony Smith and Garry J.P. Fleming and P R Cooper},
  journal={Experimental cell research},
  year={2013},
  volume={319 10},
  pages={1534-43}
}
Application of histone deacetylase inhibitors (HDACi) to cells epigenetically alters their chromatin structure and induces transcriptional and cellular reparative events. This study investigated the application of two HDACi, valproic acid (VPA) and trichostatin A (TSA) on the induction of repair-associated responses in primary dental pulp cell (DPC) cultures. Flow cytometry demonstrated that TSA (100 nM, 400 nM) significantly increased cell viability. Neither HDACi was cytotoxic, although cell… CONTINUE READING

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