Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.

@article{Akiba2010HistoneDI,
  title={Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.},
  author={Yosuke Akiba and John W Cave and Nami Akiba and Brett Langley and Rajiv R Ratan and Harriet D Baker},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={393 4},
  pages={673-7}
}
Most olfactory bulb (OB) interneurons are derived from neural stem cells in the subventricular zone (SVZ) and migrate to the OB via the rostral migratory stream (RMS). Mature dopaminergic interneurons in the OB glomerular layer are readily identified by their synaptic activity-dependent expression of tyrosine hydroxylase (TH). Paradoxically, TH is not expressed in neural progenitors migrating in the RMS, even though ambient GABA and glutamate depolarize these progenitors. In forebrain slice… CONTINUE READING