Histone deacetylase inhibitors and cell death

  title={Histone deacetylase inhibitors and cell death},
  author={Jing Zhang and Qing Zhong},
  journal={Cellular and Molecular Life Sciences},
Histone deacetylases (HDACs) are a vast family of enzymes involved in chromatin remodeling and have crucial roles in numerous biological processes, largely through their repressive influence on transcription. In addition to modifying histones, HDACs also target many other non-histone protein substrates to regulate gene expression. Recently, HDACs have gained growing attention as HDAC-inhibiting compounds are being developed as promising cancer therapeutics. Histone deacetylase inhibitors (HDACi… CONTINUE READING
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