Histone deacetylase inhibitors: new treatment options for inflammatory joint disease?


Histone deacetylase inhibitors (HDIs) are a new class of compounds that are being developed for the treatment of malignancies such as cutaneous T-cell lymphoma. HDIs inhibit the removal of acetyl groups from histones. The histone acetylation process is dependent on two enzymes, histone acetyl transferase (HAT) and histone deacetylase (HDAC), and regulates… (More)
DOI: 10.1016/j.jbspin.2010.03.009


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