Histone deacetylase inhibitors: molecular mechanisms of action

@article{Xu2007HistoneDI,
  title={Histone deacetylase inhibitors: molecular mechanisms of action},
  author={W S Xu and Raphael Bessa Parmigiani and Paul A. Marks},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={5541-5552}
}
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors (HDACi), a group of recently discovered ‘targeted’ anticancer agents. There are 18 HDACs, which are generally divided into four classes, based on sequence homology to yeast counterparts. Classical HDACi such as the hydroxamic acid-based vorinostat (also known as SAHA and Zolinza) inhibits classes I, II and IV, but not the NAD+-dependent class III enzymes. In clinical trials, vorinostat has activity against… CONTINUE READING
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