Histone deacetylase inhibitor-induced cellular apoptosis involves stanniocalcin-1 activation.

Abstract

Our previous studies have demonstrated the involvement of HIF-1 and p53 in the regulation of stanniocalcin-1 (STC1) gene transcription in human cancer cells. In this study, we reported that the treatment of human colon adenoma HT29 cells with a histone deacetylase (HDAC) inhibitor (i.e. trichostatin A, TSA) induced both cellular apoptosis and STC1… (More)
DOI: 10.1016/j.yexcr.2008.07.002

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