Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.

@article{Kumagai2007HistoneDI,
  title={Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.},
  author={Takashi Kumagai and Naoki Wakimoto and Dong Yin and Sigal Gery and Norihiko Kawamata and Noriyuki Takai and Naoki Komatsu and Alexy Chumakov and Yasufumi Imai and H Phillip Koeffler},
  journal={International journal of cancer},
  year={2007},
  volume={121 3},
  pages={656-65}
}
Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. In this study, we investigated the effects of a HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA) on pancreatic cancer cells. SAHA inhibited the growth of 6 pancreatic cancer cell lines in a dose-dependent manner… CONTINUE READING
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