Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo

@article{Sawa2004HistoneDI,
  title={Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo},
  author={Hiroki Sawa and Hiromi Murakami and Masaoki Kumagai and Matsuyoshi Nakasato and Shigeru Yamauchi and Nozomu Matsuyama and Yasuo Tamura and Akira Satone and Wataru Ide and Ikuo Hashimoto and Hajime Kamada},
  journal={Acta Neuropathologica},
  year={2004},
  volume={107},
  pages={523-531}
}
We investigated the effects of FK228 on cell proliferation and apoptosis against human glioblastoma (GM) T98G, U251MG, and U87MG cells. Upon exposure to FK228, cell proliferation was inhibited, and apoptosis detected by the cleavage of CPP32 was induced. FK228 increased the expression levels of p21 (WAF-1) and of pro-apoptotic Bad protein in all GM cells. Furthermore, FK228 treatment also reduced the anti-apoptotic protein Bcl-xL in all GM cells and anti-apoptotic Bcl-2 in U87MG cells, thereby… CONTINUE READING

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