Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin.

@article{Liu2008HistonedeacetylaseIR,
  title={Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin.},
  author={Fang Liu and Mark D Levin and Nataliya B. Petrenko and Min Min Lu and Tao Wang and Li Jun Yuan and Andrea L. Stout and Jonathan A. Epstein and Vickas V. Patel},
  journal={Journal of molecular and cellular cardiology},
  year={2008},
  volume={45 6},
  pages={
          715-23
        }
}
Atrial fibrosis influences the development of atrial fibrillation (AF), particularly in the setting of structural heart disease where angiotensin-inhibition is partially effective for reducing atrial fibrosis and AF. Histone-deacetylase inhibition reduces cardiac hypertrophy and fibrosis, so we sought to determine if the HDAC inhibitor trichostatin A (TSA) could reduce atrial fibrosis and arrhythmias. Mice over-expressing homeodomain-only protein (HopX(Tg)), which recruits HDAC activity to… CONTINUE READING
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