Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation.

@article{Lkhagva2014HistoneDI,
  title={Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation.},
  author={Baigalmaa Lkhagva and Shih-Lin Chang and Yao-Chang Chen and Yu-Hsun Kao and Yung-Kuo Lin and Cindy Tzu-Hsuan Chiu and Shih Ann Chen and Yi-Jen Chen},
  journal={International journal of cardiology},
  year={2014},
  volume={177 3},
  pages={982-9}
}
Pulmonary veins (PVs) play a critical role in the pathophysiology of atrial fibrillation (AF). Histone deacetylases (HDACs) are vital to calcium homeostasis and AF genesis. However, the electrophysiological effects of HDAC inhibition were unclear. This study evaluated whether HDAC inhibition can regulate PV electrical activity through calcium modulation. Whole-cell patch-clamp, confocal microscopic with fluorescence, and Western blot were used to evaluate electrophysiological characteristics… CONTINUE READING
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Histonedeacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure

  • KaoYH, JP Liou, ChungCC, LienGS, KuoCC, SA Chen
  • Int J Cardiol
  • 2013
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