Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor.

@article{Gilbert2011HistoneDI,
  title={Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor.},
  author={Richard E Gilbert and Qingling Huang and Kerri Thai and Suzanne L. Advani and Kodie Lee and Darren A. Yuen and Kim A Connelly and Andrew H. Advani},
  journal={Kidney international},
  year={2011},
  volume={79 12},
  pages={1312-21}
}
Clinical trials and experimental studies have highlighted the importance of epigenetic processes in the development of diabetic complications. One of the earliest features of diabetic nephropathy is renal enlargement. The epidermal growth factor (EGF) has a pivotal role in the development of diabetic nephromegaly and transactivation of its receptor has been implicated in the pathogenesis of later-stage disease. As EGF signaling is altered by the acetylation status of histone proteins, we… CONTINUE READING