Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation.

  title={Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation.},
  author={Reinhard Brunmeir and Sabine Lagger and Christian Seiser},
  journal={The International journal of developmental biology},
  volume={53 2-3},
During development from the fertilized egg to a multicellular organism, cell fate decisions have to be taken and cell lineage or tissue-specific gene expression patterns are created and maintained. These alterations in gene expression occur in the context of chromatin structure and are controlled by chromatin modifying enzymes. Gene disruption studies in different genetic systems have shown an essential role of various histone deacetylases (HDACs) during early development and cellular… CONTINUE READING
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