Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.

Abstract

Skeletal muscle atrophy is a severe condition of muscle mass loss. Muscle atrophy is caused by a down-regulation of protein synthesis and by an increase of protein breakdown due to the ubiquitin-proteasome system and autophagy activation. Up-regulation of specific genes, such as the muscle-specific E3 ubiquitin ligase MAFbx, by FoxO transcription factors is… (More)
DOI: 10.1074/jbc.M114.600916

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Cite this paper

@article{Ratti2015HistoneD6, title={Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.}, author={Francesca Ratti and Francis Ramond and Vincent Moncollin and Thomas Simonet and Giulia Milan and Alexandre M{\'e}jat and J Thomas and Nathalie Streichenberger and Beno{\^i}t Gilquin and Patrick Matthias and Saadi Khochbin and Marco Sandri and Laurent Schaeffer}, journal={The Journal of biological chemistry}, year={2015}, volume={290 7}, pages={4215-24} }