Histone deacetylase 4 possesses intrinsic nuclear import and export signals.

@article{Wang2001HistoneD4,
  title={Histone deacetylase 4 possesses intrinsic nuclear import and export signals.},
  author={Audrey H. Wang and Xiang Jiao Yang},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 17},
  pages={5992-6005}
}
Nucleocytoplasmic trafficking of histone deacetylase 4 (HDAC4) plays an important role in regulating its function, and binding of 14-3-3 proteins is necessary for its cytoplasmic retention. Here, we report the identification of nuclear import and export sequences of HDAC4. While its N-terminal 118 residues modulate the nuclear localization, residues 244 to 279 constitute an authentic, strong nuclear localization signal. Mutational analysis of this signal revealed that three arginine-lysine… CONTINUE READING
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