Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation.

@article{Glnisson2007HistoneD4,
  title={Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation.},
  author={Wendy Gl{\'e}nisson and Vincent Castronovo and David Waltregny},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1773 10},
  pages={1572-82}
}
Transforming Growth Factor beta1 (TGFbeta1) is a crucial cytokine triggering myofibroblastic (MF) differentiation, a process involved in tissue healing as well as in pathologic conditions such as fibrosis and cancer. Together with cell shape modifications, TGFbeta1-mediated differentiation of fibroblasts into myofibroblasts is characteristically associated with the neo-expression of smooth muscle alpha-actin (alpha-SMA), a cytoskeletal protein that enhances their contractile activity. Several… CONTINUE READING