Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

@article{Kao2003HistoneD4,
  title={Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response},
  author={Gary D. Kao and W. Gillies Mckenna and Matthew G. Guenther and Ruth J. Muschel and Mitchell A Lazar and Tim J. Yen},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={160},
  pages={1017 - 1027}
}
Anumber of proteins are recruited to nuclear foci upon exposure to double-strand DNA damage, including 53BP1 and Rad51, but the precise role of these DNA damage-induced foci remain unclear. Here we show in a variety of human cell lines that histone deacetylase (HDAC) 4 is recruited to foci with kinetics similar to, and colocalizes with, 53BP1 after exposure to agents causing double-stranded DNA breaks. HDAC4 foci gradually disappeared in repair-proficient cells but persisted in repair-deficient… CONTINUE READING

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