Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.

@article{Jung2010HistoneD3,
  title={Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase.},
  author={S Y Jung and Cuk-Seong Kim and Asma S. Naqvi and Tohru Yamamori and Ilwola Mattagajasingh and Timothy A. Hoffman and Marsha P Cole and Ajay Kumar and Jeremy S Dericco and Byeong-hwa Jeon and Kaikobad Irani},
  journal={Circulation research},
  year={2010},
  volume={107 7},
  pages={877-87}
}
RATIONALE Low-dose acetylsalicylic acid (aspirin) is widely used in the treatment and prevention of vascular atherothrombosis. Cardiovascular doses of aspirin also reduce systemic blood pressure and improve endothelium-dependent vasorelaxation in patients with atherosclerosis or risk factors for atherosclerosis. Aspirin can acetylate proteins, other than its pharmacological target cyclooxygenase, at lysine residues. The role of lysine acetylation in mediating the effects of low-dose aspirin on… CONTINUE READING
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