Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

  title={Histone deacetylase 10 structure and molecular function as a polyamine deacetylase},
  author={Yang Hai and Stephen A Shinsky and Nicholas J Porter and David W Christianson},
  booktitle={Nature communications},
Cationic polyamines such as spermidine and spermine are critical in all forms of life, as they regulate the function of biological macromolecules. Intracellular polyamine metabolism is regulated by reversible acetylation and dysregulated polyamine metabolism is associated with neoplastic diseases such as colon cancer, prostate cancer and neuroblastoma. Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Homo sapiens (human) and… CONTINUE READING
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