Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice

@inproceedings{Dovey2013HistoneD,
  title={Histone deacetylase (HDAC) 1 and 2 are essential for normal T cell development and genomic stability in mice},
  author={Oliver M Dovey and George Vasilliou and Adrienne Bradley and Shaun M Cowley},
  booktitle={Clinical Epigenetics},
  year={2013}
}
The highly related enzymes, histone deacetylase 1 and 2 (HDAC1/2), regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand their role in the adaptive immune system and inform their exploitation as drug targets, we have generated mice with a T-cell specific inactivation of both Hdac1/2 genes. Loss of either HDAC1 or HDAC2 alone has little effect, while dual inactivation results in a 5-fold reduction in thymocyte cellularity… CONTINUE READING
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