Histone arginine methylation keeps RUNX1 target genes in an intermediate state

@article{Herglotz2013HistoneAM,
  title={Histone arginine methylation keeps RUNX1 target genes in an intermediate state},
  author={Julia Herglotz and Olga N. Kuvardina and Stephan Kolodziej and Ajay Kumar and Helge Hussong and Manuel Grez and Joern Lausen},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={2565-2575}
}
The coordinated recruitment of epigenetic regulators of gene expression by transcription factors such as RUNX1 (AML1, acute myeloid leukemia 1) is crucial for hematopoietic differentiation. Here, we identify protein arginine methyltransferase 6 (PRMT6) as a central functional component of a RUNX1 corepressor complex containing Sin3a and HDAC1 in human hematopoietic progenitor cells. PRMT6 is recruited by RUNX1 and mediates asymmetric histone H3 arginine-2 dimethylation (H3R2me2a) at… CONTINUE READING

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genes during differentiation. Cell stem cell

  • H Oguro, J Yuan, H Ichikawa, T Ikawa, S Yamazaki, H Kawamoto
  • 2010

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