Histone arginine methylation in cocaine action in the nucleus accumbens.

  title={Histone arginine methylation in cocaine action in the nucleus accumbens.},
  author={Diane M Damez-Werno and Haosheng Sun and Kimberly N. Scobie and Ningyi Shao and Jaclyn Rabkin and Caroline Odebrecht Dias and Erin S. Calipari and Ian Maze and Catherine Jensen Pe{\~n}a and Deena M Walker and Michael E Cahill and Ramesh Chandra and Amy M. Gancarz and Ezekiell A Mouzon and Joseph A Landry and Hannah M Cates and Mary-Kay Lobo and David M Dietz and C David Allis and Ernesto Guccione and Gustavo Turecki and Paola Defilippi and Rachael Lee Neve and Yasmin L Hurd and Li Shen and Eric J Nestler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 34},
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation and methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast to Lys methylation, the role of histone Arg (R) methylation remains underexplored in addiction models. Here we show that protein-R-methyltransferase-6 (PRMT6) and its associated histone mark, asymmetric dimethylation of R2 on histone H3 (H3R2me2a… CONTINUE READING
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