Histone acetyltransferases: function, structure, and catalysis.

  title={Histone acetyltransferases: function, structure, and catalysis.},
  author={Ronen Marmorstein and Sharon Y. Roth},
  journal={Current opinion in genetics & development},
  volume={11 2},
Histone acetyltransferases (HATs) directly link chromatin modification to gene activation. Recent structure/function studies provide insights into HAT catalysis and histone binding, and genetic studies suggest cross-talk between acetylation and other histone modifications. Developmental aberrations in mice and certain human cancers are associated with HAT… CONTINUE READING