Histone acetyltransferases: challenges in targeting bi-substrate enzymes

  title={Histone acetyltransferases: challenges in targeting bi-substrate enzymes},
  author={Hannah Wapenaar and Frank J Dekker},
  booktitle={Clinical Epigenetics},
Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors, and enzymes. HATs have been shown to play a role in diseases ranging from cancer and inflammatory diseases to neurological disorders, both through acetylations of histone proteins and non-histone proteins. Several HAT inhibitors, like bi-substrate inhibitors, natural product derivatives, small molecules, and… CONTINUE READING
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