Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.

@article{Xiao2010HistoneAM,
  title={Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.},
  author={Yan Ping Xiao and Bin Li and Zhaocai Zhou and Wayne W Hancock and Hongtao Zhang and Margaret C. L. Greene},
  journal={Current opinion in immunology},
  year={2010},
  volume={22 5},
  pages={
          583-91
        }
}
Regulatory T cells (Tregs) are required for the maintenance of immune homeostasis as first clearly described by Herman Waldmann's laboratory. Dysfunction of Treg cells also leads to fatal autoimmunity in humans and mice. Conversely, the activation of different classes of Tregs operative systemically and within the cancer microenvironment can suppress host anti-tumor immune responses and promote tumor progression. Therefore, the development of new therapeutic approaches to regulate the activity… CONTINUE READING
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