Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.

@article{Iizuka1999HistoneAH,
  title={Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.},
  author={Masayoshi Iizuka and Bruce W. Stillman},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 33},
  pages={23027-34}
}
The origin recognition complex (ORC) is an initiator protein for DNA replication, but also effects transcriptional silencing in Saccharomyces cerevisiae and heterochromatin function in Drosophila. It is not known, however, whether any of these functions of ORC is conserved in mammals. We report the identification of a novel protein, HBO1 (histone… CONTINUE READING