Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice

@article{Itzhak2012HistoneAR,
  title={Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice},
  author={Yossef Itzhak and Karen L. Anderson and Jonathan Burke Kelley and Martin Petkov},
  journal={Neurobiology of Learning and Memory},
  year={2012},
  volume={97},
  pages={409-417}
}
Epigenetic regulation of chromatin structure is an essential molecular mechanism that contributes to the formation of synaptic plasticity and long-term memory (LTM). An important regulatory process of chromatin structure is acetylation and deacetylation of histone proteins. Inhibition of histone deacetylase (HDAC) increases acetylation of histone proteins and facilitate learning and memory. Nitric oxide (NO) signaling pathway has a role in synaptic plasticity, LTM and regulation of histone… CONTINUE READING

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