Histone acetylation reduces nucleosome core particle linking number change.

@article{Norton1989HistoneAR,
  title={Histone acetylation reduces nucleosome core particle linking number change.},
  author={V G Norton and Brian S. Imai and Patrick Yau and E. Morton Bradbury},
  journal={Cell},
  year={1989},
  volume={57 3},
  pages={449-57}
}
Nucleosome core particles differing in their levels of histone acetylation have been formed on a closed circular DNA that contains a tandemly repeated 207 bp nucleosome positioning sequence. The effect of acetylation on the linking number per nucleosome particle has been determined. With increasing levels of acetylation, the negative linking number change per nucleosome decreases from -1.04 +/- 0.08 for control to -0.82 +/- 0.05 for highly acetylated nucleosomes. These results indicate that… CONTINUE READING
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