Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.

Abstract

During T-cell development, Cd8 expression is controlled via dynamic regulation of its cis-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated Cd8 expression in CD4(+)CD8(+) double-positive (DP) thymocytes. Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT) complex responsible for acetylation of histone H3 at lysine… (More)
DOI: 10.1038/ncomms6872

7 Figures and Tables

Topics

  • Presentations referencing similar topics