Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.

@article{Shen2002HistoneAI,
  title={Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.},
  author={Jiali Shen and Mart{\'i}n A. Montecino and Jane B Lian and Gary S Stein and Andre J van Wijnen and Janet L Stein},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 23},
  pages={20284-92}
}
The accessibility of regulatory elements in chromatin represents a principal rate-limiting parameter of gene transcription and is modulated by enzymatic transcriptional co-factors that alter the topology of chromatin or covalently modify histones (e.g. by acetylation). The bone-specific activation and 1,25-dihydroxyvitamin D(3) enhancement of osteocalcin (OC) gene transcription are both functionally linked to modifications in nucleosomal organization. The initiation of tissue-specific basal… CONTINUE READING
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