Histone acetylation and deacetylation in yeast

  title={Histone acetylation and deacetylation in yeast},
  author={Siavash K Kurdistani and Michael R. Grunstein},
  journal={Nature Reviews Molecular Cell Biology},
Histone acetylation and deacetylation in the yeast Saccharomyces cerevisiae occur by targeting acetyltransferase and deacetylase enzymes to gene promoters and, in an untargeted and global manner, by affecting most nucleosomes. Recently, new roles for histone acetylation have been uncovered, not only in transcription but also in DNA replication, repair and heterochromatin formation. Interestingly, specific acetylatable lysines can function as binding sites for regulatory factors. Moreover… CONTINUE READING
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