Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.

@article{Cosio2004HistoneAA,
  title={Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.},
  author={Borja G Cosio and Buphinder Mann and Kazuhiro Ito and Elen P I Jazrawi and Peter J Barnes and Kian Fan Chung and Ian M. Adcock},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={170 2},
  pages={141-7}
}
Histone acetylation status is a key factor in the regulation of inflammatory gene transcription. We investigated the activity of histone acetylases (HAT) and deacetylases (HDAC), and the effect of glucocorticoids in alveolar macrophages (AM) and peripheral blood mononuclear cells (PBMC) from subjects with asthma. Bronchoalveolar lavage was performed in 10 patients with intermittent asthma, 8 with persistent asthma, and 10 healthy control subjects. PBMCs and granulocytes were isolated from six… CONTINUE READING
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Histone deacetylase activity is reduced in alveolar macrophages but not blood mononuclear cells in asthmatics [abstract

  • BG Cosio, BS Mann, E Jazrawi, IM Adcock, KF Chung, PJ. Barnes
  • Am J Respir Crit Care Med 2003;167:A482
  • 2003
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