Histone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus

@inproceedings{Mandal2015HistoneRB,
  title={Histone Reader BRWD1 Targets and Restricts Recombination to the Igk Locus},
  author={Malay Mandal and Keith M. Hamel and Mark Maienschein-Cline and Azusa Tanaka and Grace Teng and Jigyasa H Tuteja and Jeffrey J Bunker and Neil Bahroos and John J. Eppig and David G Schatz and Marcus R. Clark},
  booktitle={Nature Immunology},
  year={2015}
}
B lymphopoiesis requires that immunoglobulin genes be accessible to RAG1-RAG2 recombinase. However, the RAG proteins bind widely to open chromatin, which suggests that additional mechanisms must restrict RAG-mediated DNA cleavage. Here we show that developmental downregulation of interleukin 7 (IL-7)-receptor signaling in small pre-B cells induced expression of the bromodomain-family member BRWD1, which was recruited to a specific epigenetic landscape at Igk dictated by pre-B cell receptor (pre… CONTINUE READING
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