Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

@inproceedings{Popovic2014HistoneMM,
  title={Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation},
  author={Relja Popovic and Eva Mart{\'i}nez-Garc{\'i}a and Eugenia G. Giannopoulou and Quanwei Zhang and Qingyang Zhang and Teresa Ezponda and Mrinal Y. Shah and Yupeng Zheng and Christine M. Will and Eliza C. Small and Youjia Hua and Marinka Bulic and Yanwen Jiang and Matteo Carrara and Raffaele Adolfo Calogero and William L. Kath and Neil L. Kelleher and Ji-Ping Wang and Olivier Elemento and Jonathan D Licht},
  booktitle={PLoS genetics},
  year={2014}
}
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and its overexpression causes a global increase in H3K36me2, redistributing this mark in a broad, elevated level across the genome. Here, we demonstrate that an increased level of MMSET also induces a global reduction of lysine 27 trimethylation on… CONTINUE READING
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