Histone H4 and the maintenance of genome integrity.

  title={Histone H4 and the maintenance of genome integrity.},
  author={Paul C. Megee and Barry A Morgan and M Mitchell Smith},
  journal={Genes & development},
  volume={9 14},
The normal progression of Saccharomyces cerevisiae through nuclear division requires the function of the amino-terminal domain of histone H4. Mutations that delete the domain, or alter 4 conserved lysine residues within the domain, cause a marked delay during the G2+M phases of the cell cycle. Site-directed mutagenesis of single and multiple lysine residues failed to map this phenotype to any particular site; the defect was only observed when all four lysines were mutated. Starting with a… CONTINUE READING


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