Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma.

@article{Toh2003HistoneHA,
  title={Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma.},
  author={Yasushi Toh and Manabu Yamamoto and Kazuya Endo and Yasuharu Ikeda and Hideo Baba and Shunji Kohnoe and Hirotoshi Yonemasu and Yoichi Hachitanda and Takeshi Okamura and Keizo Sugimachi},
  journal={Oncology reports},
  year={2003},
  volume={10 2},
  pages={333-8}
}
The alterations of the chromatin structure by histone acetylases (HATs) and histone deacetylases (HDACs) are implicated in the regulation of gene transcription and also in the process of carcinogenesis. HDAC inhibitors have been shown to be potent inducers of growth arrest, differentiation and/or apoptotic cell death of transformed cells and, as a result, they are currently receiving considerable attention as antitumor agents. In this study, we examined the status of histone H4 acetylation and… CONTINUE READING