Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

@article{Yuan2012HistoneHS,
  title={Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.},
  author={Chih-Chi Yuan and Adam Matthews and Yi Jin and Chang Feng Chen and Brad A. Chapman and Toshiro K. Ohsumi and Karen C Glass and Tatiana G Kutateladze and Mark L. Borowsky and Kevin Struhl and Marjorie A. Oettinger},
  journal={Cell reports},
  year={2012},
  volume={1 2},
  pages={83-90}
}
The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence of the previously unknown histone modification H3R2me2s. Here, we report the in vivo identification of… CONTINUE READING