Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast

@inproceedings{Suzuki2016HistoneHT,
  title={Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast},
  author={Shota Suzuki and Hiroaki Kato and Yutaka Suzuki and Yuji Chikashige and Yasushi Hiraoka and Hiroshi Kimura and Koji Nagao and Chikashi Obuse and Shinya Takahata and Yota Murakami},
  booktitle={Nucleic acids research},
  year={2016}
}
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its Set2-Rpb1 interaction (SRI) domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 is sufficient for recruitment of the Rpd3S histone deacetylase complex to repress cryptic transcription from transcribed regions. In fission yeast, Set2 is also responsible for H3K36 methylation, which represses a subset of RNAs including… CONTINUE READING
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Understanding the language of Lys36 methylation at histone H3

Nature Reviews Molecular Cell Biology • 2012
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