Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

@article{Cribbs2020HistoneHD,
  title={Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism},
  author={A. Cribbs and S. Terlecki-Zaniewicz and M. Philpott and J. Baardman and D. Ahern and M. Lindow and S. Obad and H. Oerum and B. Sampey and P. Mander and H. Penn and P. Wordsworth and P. Bowness and M. D. de Winther and R. Prinjha and M. Feldmann and U. Oppermann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2020},
  volume={117},
  pages={6056 - 6066}
}
Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability. Epigenetic mechanisms controlling metabolic functions in T cells are currently not well-defined. Here, we establish an epigenetic link between the histone H3K27me3 demethylases KDM6A/B and the coordination of a metabolic response. Inhibition of KDM6A/B leads to global… Expand
8 Citations

References

SHOWING 1-10 OF 100 REFERENCES
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation.
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism
CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells.
Epigenetic regulation of the alternatively activated macrophage phenotype.
...
1
2
3
4
5
...