Histone H3.3 and its proteolytically processed form drive a cellular senescence program

@inproceedings{Duarte2014HistoneHA,
  title={Histone H3.3 and its proteolytically processed form drive a cellular senescence program},
  author={Luis Fc Duarte and Andrew J. Young and Zichen Wang and Hsan-au Wu and Taniya Panda and Yan Kou and Avnish Kapoor and Dan Hasson and Nicholas R. Mills and Avi Ma’ayan and Masashi Narita and Emily M Bernstein},
  booktitle={Nature communications},
  year={2014}
}
The process of cellular senescence generates a repressive chromatin environment, however, the role of histone variants and histone proteolytic cleavage in senescence remains unclear. Here, using models of oncogene-induced and replicative senescence, we report novel histone H3 tail cleavage events mediated by the protease Cathepsin L. We find that cleaved forms of H3 are nucleosomal and the histone variant H3.3 is the preferred cleaved form of H3. Ectopic expression of H3.3 and its cleavage… CONTINUE READING
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