Histone H3 methylation links DNA damage detection to activation of the Tip60 tumor suppressor

@inproceedings{Sun2009HistoneHM,
  title={Histone H3 methylation links DNA damage detection to activation of the Tip60 tumor suppressor},
  author={Yingli Sun and Xiaofeng Jiang and Ye Xu and Marina K. Ayrapetov and Lisa A. Moreau and Johnathan R. Whetstine and Brendan D. Price},
  booktitle={Nature Cell Biology},
  year={2009}
}
DNA double-strand break (DSB) repair involves complex interactions between chromatin and repair proteins, including Tip60, a tumour suppressor. Tip60 is an acetyltransferase that acetylates both histones and ATM (ataxia telangiectasia mutated) kinase. Inactivation of Tip60 leads to defective DNA repair and increased cancer risk. However, how DNA damage activates the acetyltransferase activity of Tip60 is not known. Here, we show that direct interaction between the chromodomain of Tip60 and… CONTINUE READING
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