Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

@article{Herz2014HistoneHL,
  title={Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling},
  author={H. Herz and Marc Morgan and Xin Gao and Jessica Jackson and Ryan Rickels and Selene K Swanson and Laurence Florens and Michael P Washburn and Joel C. Eissenberg and Ali Shilatifard},
  journal={Science},
  year={2014},
  volume={345},
  pages={1065-1070}
}
Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model for the pathogenic histone H3K27M mutation and show that its overexpression resembles polycomb repressive complex 2 (PRC2) loss-of-function phenotypes, causing derepression of PRC2 target genes and developmental perturbations. Similarly, an H3K9M mutant depletes H3K9 methylation levels and suppresses position-effect variegation in various… CONTINUE READING