Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning

@article{Hiraga2008HistoneHL,
  title={Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning},
  author={Shin-ichiro Hiraga and Sotirios Botsios and Anne D. Donaldson},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={183},
  pages={641 - 651}
}
Correct intranuclear organization of chromosomes is crucial for many genome functions, but the mechanisms that position chromatin are not well understood. We used a layered screen to identify Saccharomyces cerevisiae mutants defective in telomere localization to the nuclear periphery. We find that events in S phase are crucial for correct telomere localization. In particular, the histone chaperone Asf1 functions in telomere peripheral positioning. Asf1 stimulates acetylation of histone H3… CONTINUE READING

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