Histone H3 as a novel substrate for MAP kinase phosphatase-1.

Abstract

Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) is a nuclear, dual-specificity phosphatase that has been shown to dephosphorylate MAP kinases. We used a "substrate-trap" technique involving a mutation in MKP-1 of the catalytically critical cysteine to a serine residue ("CS" mutant) to capture novel MKP-1 substrates. We transfected the MKP-1 (CS… (More)
DOI: 10.1152/ajpcell.00492.2008

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@article{Kinney2009HistoneHA, title={Histone H3 as a novel substrate for MAP kinase phosphatase-1.}, author={Corttrell M Kinney and Unni M. Chandrasekharan and Lin Yang and Jianzhong Shen and Michael T. Kinter and Michael S McDermott and Paul E. Dicorleto}, journal={American journal of physiology. Cell physiology}, year={2009}, volume={296 2}, pages={C242-9} }