Histone H3-K9 methyltransferase ESET is essential for early development.

  title={Histone H3-K9 methyltransferase ESET is essential for early development.},
  author={Jonathan Dodge and Yong Kook Kang and Hideyuki Beppu and Hong Lei and En Li},
  journal={Molecular and cellular biology},
  volume={24 6},
Methylation of histone H3 at lysine 9 (H3-K9) mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing gene expression at euchromatic sites. ESET, G9a, SUV39-h1, SUV39-h2, and Eu-HMTase are histone methyltransferases that catalyze H3-K9 methylation in mammalian cells. Previous studies demonstrate that the SUV39-h proteins are preferentially targeted to the pericentric heterochromatin, and mice lacking both Suv39-h genes show cytogenetic… CONTINUE READING
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