Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.

  title={Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.},
  author={Ivana Celic and Alain Verreault and Jef D. Boeke},
  volume={179 4},
Deacetylation of histone H3 K56, regulated by the sirtuins Hst3p and Hst4p, is critical for maintenance of genomic stability. However, the physiological consequences of a lack of H3 K56 deacetylation are poorly understood. Here we show that cells lacking Hst3p and Hst4p, in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage, such as activation of the checkpoint kinase Rad53p and upregulation of DNA-damage inducible genes. Consistently, hst3 hst4 cells… CONTINUE READING


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The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway.

Proceedings of the National Academy of Sciences of the United States of America • 1997

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