Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.

@article{Ingvarsdttir2007HistoneHK,
  title={Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.},
  author={Krist{\'i}n {\'O}sk Ingvarsd{\'o}ttir and Chris Edwards and Min Gyu Lee and Jung Shin Lee and David C. Schultz and Ali Shilatifard and Ramin Shiekhattar and Shelley L Berger},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 22},
  pages={7856-64}
}
In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji class. The enzymes of the jumonji class in the yeast Saccharomyces cerevisiae have recently also been shown to have lysine demethylation activity. Here we report that the protein encoded by YJR119c (termed KDM5), coding for one of five predicted jumonji domain proteins in yeast, specifically demethylates trimethylated histone H3 lysine 4 (H3K4me3), H3K4me2, and… CONTINUE READING

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