Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae

@article{Ingvarsdttir2007HistoneHK,
  title={Histone H3 K4 Demethylation during Activation and Attenuation of GAL1 Transcription in Saccharomyces cerevisiae},
  author={K. Ingvarsd{\'o}ttir and C. Edwards and Min Gyu Lee and Jung Shin Lee and D. C. Schultz and A. Shilatifard and R. Shiekhattar and S. Berger},
  journal={Molecular and Cellular Biology},
  year={2007},
  volume={27},
  pages={7856 - 7864}
}
ABSTRACT In mammalian cells, histone lysine demethylation is carried out by two classes of enzymes, the LSD1/BHC110 class and the jumonji class. The enzymes of the jumonji class in the yeast Saccharomyces cerevisiae have recently also been shown to have lysine demethylation activity. Here we report that the protein encoded by YJR119c (termed KDM5), coding for one of five predicted jumonji domain proteins in yeast, specifically demethylates trimethylated histone H3 lysine 4 (H3K4me3), H3K4me2… Expand
Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions.
TLDR
The results show that Rph1 is the demethylase that is specific for hist one H3K36 trimethylation during transcription elongation in vivo, and the abilities of other endogenous JmjC demethylasesto demethylate histone H3 are weak toward histoneH3 in actively transcribed regions. Expand
Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae
TLDR
It is demonstrated that loss of the histone H3-specific acetyltransferases (HATs) resulted in genome-wide depletion of H3K4me3, and this was not due to a transcription defect. Expand
Dissecting the Role of the Jumonji Family Member Jhd2p, a Histone Lysine Demethylase
In Saccharomyces cerevisiae, Set1p-mediated deposition of trimethylation on lysine 4 of histone H3 is a histone modification often associated with active transcription. Recently, it was discoveredExpand
H3K4 Methylation Dependent and Independent Chromatin Regulation by JHD2 and SET1 in Budding Yeast
TLDR
The findings suggest some of the chromatin regulatory functions of Set1 are independent of H3K4 methylation, and confirm and extend an emerging role for Jhd2 in the control of nucleosome occupancy near transcription start sites. Expand
H3K4 methylation dependent and independent chromatin regulation by JHD2 and SET1 in budding yeast
TLDR
The findings suggest some of the chromatin regulatory functions of Set1 are independent of H3K4 methylation, and confirm and extend an emerging role for Jhd2 in the control of nucleosome occupancy near transcription start sites. Expand
Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression.
TLDR
It is proposed that Not4 is an E3 ubiquitin ligase that monitors and controls a precise amount of Jhd2 protein so that the proper balance between histone demethylase and histone methyltransferase activities occur in the cell, ensuring appropriate levels of H3 K4 trimethylation and gene expression. Expand
Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast
TLDR
It is expected that the rich variety of post-translational modifications that decorates the histone methylation machinery will explain many of the unresolved questions surrounding the function and dynamics of this intricate epigenetic network. Expand
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic ribosomal DNA condensation
TLDR
Yeast Jhd2, which demethylates histone H3 Lys4 near the rDNA locus, regulates rDNA repeat stability and rDNA silencing in a Sir2-independent manner by maintaining Csm1/Lrs4 and condensin association with rDNA regions during mitosis. Expand
The JmjN Domain of Jhd2 Is Important for Its Protein Stability, and the Plant Homeodomain (PHD) Finger Mediates Its Chromatin Association Independent of H3K4 Methylation*♦
TLDR
These findings provide a mechanistic explanation for the observed defects in patients harboring this SMCX mutant and suggest the presence of a conserved pathway involving Not4 that modulates the protein stability of both yeast Jhd2 and humanSMCX. Expand
Tolerance of DNA Replication Stress Is Promoted by Fumarate Through Modulation of Histone Demethylation and Enhancement of Replicative Intermediate Processing in Saccharomyces cerevisiae
TLDR
It is reported that Saccharomyces cerevisiae fumarase, Fum1p, acts as a response factor during DNA replication stress, and fumarate enhances survival of yeast lacking Htz1p (H2A.Z in mammals), implying metabolic enzymes and metabolites aid in processing replicative intermediates by affecting chromatin modification states, thereby promoting genome integrity. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
The Saccharomyces cerevisiae Histone Demethylase Jhd1 Fine-Tunes the Distribution of H3K36me2
TLDR
These studies establish JHD1 as a histone demethylase in budding yeast and suggest that Jhd1 functions to maintain the fidelity of histone methylation patterns along transcription units. Expand
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.
TLDR
Chromatin immunoprecipitation assays show that H3 Lys4 methylation is present at the rDNA locus and that Set1-mediated H3 lysine 4 (Lys4)methylation is required for repression of RNA polymerase II transcription within rDNA, and suggest that Set 1-mediatedH3 Lys 4 methylation are required for normal cell growth and transcriptional silencing. Expand
The Fission Yeast Jmj2 Reverses Histone H3 Lysine 4 Trimethylation*
TLDR
It is shown that the JmJC protein Jmj2, which is evolutionarily conserved from yeast to human, reversed trimethylated H3-Lys-4 to di- and mono-but not unmethylated products. Expand
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
TLDR
It is demonstrated that the JARID1 proteins RBP2, PLU1, and SMCX are histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4) and that mutation or RNAi depletion of the C. elegans JARid1 homolog rbr-2 leads to increased levels of H3K 4me3 during larval development and defects in vulva formation. Expand
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
TLDR
The finding that this family of demethylases generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation. Expand
Histone demethylation by a family of JmjC domain-containing proteins
TLDR
The JmjC domain is identified as a novel demethylase signature motif and a protein demethylation mechanism that is conserved from yeast to human is uncovered. Expand
Two Saccharomyces cerevisiae JmjC Domain Proteins Demethylate Histone H3 Lys36 in Transcribed Regions to Promote Elongation*♦
TLDR
It is shown that overexpression of either Jhd1 or Rph1, two JmjC-domain proteins, bypasses the requirement for the positive elongation factor gene BUR1, and this indicates that a general function of histone demethylases for H3 Lys36 is to promote transcription elongation by antagonizing repressive Lys36 methylation by Set2. Expand
Identification of Histone Demethylases in Saccharomyces cerevisiae*
TLDR
Three novel JmjC domain-containing histone demethylases and their sites of action in budding yeast S. cerevisiae are identified and the methodology described here will be useful for identifying hist one demethylase and their target sites in other organisms. Expand
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
TLDR
In addition to identifying GASC1 as a histone trimethyl demethylase, this work suggests a model for how this enzyme might be involved in cancer development, and proposes it as a target for anti-cancer therapy. Expand
Physical and Functional Association of a Trimethyl H3K4 Demethylase and Ring6a/MBLR, a Polycomb-like Protein
TLDR
Depletion of JARID1d enhanced recruitment of the chromatin remodeling complex, NURF, and the basal transcription machinery near the transcriptional start site, revealing a role for JARIDs1d in regulation of transcriptional initiation through H3K4 demethylation. Expand
...
1
2
3
4
5
...