Histone H2A.Z is essential for estrogen receptor signaling.

  title={Histone H2A.Z is essential for estrogen receptor signaling.},
  author={Nicolas Gevry and Sara Hardy and Pierre-{\'E}tienne Jacques and Liette Laflamme and Amy Svotelis and François Robert and Luc Gaudreau},
  journal={Genes & development},
  volume={23 13},
Incorporation of H2A.Z into the chromatin of inactive promoters has been shown to poise genes for their expression. Here we provide strong evidence that H2A.Z is incorporated into the promoter regions of estrogen receptor (ERalpha) target genes only upon gene induction, and that, in a cyclic pattern. Moreover, members of the human H2A.Z-depositing complex, p400, also follow the same gene recruitment kinetics as H2A.Z. Importantly, cellular depletion of H2A.Z or p400 leads to a severe defect in… CONTINUE READING
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